Topas Overcoming Tetramer-Based Detection Challenges Integrating Trial Design, Endpoint Selection & Analytical Methods to Evaluate AntigenSpecific Tolerance Induction
- Integration of biology with clinical trial design to evaluate antigen-specific tolerance induction, drawing on Phase I and II experience across celiac disease
- Endpoint selection guided by both mechanistic and clinical relevance, including strategies for incorporating non-invasive biomarkers and disease-appropriate readouts
- Analytical methods used to assess antigen-specific responses and evolving approaches to improve sensitivity and reliability