Jason Noon
Director, Immunology Discovery AbbVie
Seminars
Thursday 5th March 2026
Beyond B-Cell Depletion: Targeting Pathogenic T & Myeloid Cell Subsets to Achieve Durable Autoimmune Remission
11:00 am
- Explores T-cell subsets beyond B-cell depletion—particularly tissue-resident memory, follicular helper, and peripheral helper T cells—as key drivers of autoimmune persistence and B-cell activation
- Examines evidence that selective depletion or modulation of these T-cell and myeloid populations may deliver deep, durable disease control comparable to B-cell–targeted approaches
- Addresses translational challenges including efficient tissue-level depletion, optimizing delivery and biodistribution of therapeutic modalities, and defining biomarkers that capture local immune modulation
