Antigen-Specific Tolerance to Multiple Epitopes in T1D
Time: 3:30 pm
day: Day One
Details:
- Discussing how antigen-specific tolerance to multiple proteins stops progression to overt diabetes in the NOD model
- Tolerance induction by CNP-T1D included upregulation Tregs and TR1 cell populations, which resulted in inhibition of activation of diabetogenic epitopes not encapsulated within CNP
- The CNP-T1D induced tolerance was durable to the end of the study and also
prevented infiltration into the islets
