Antigen-Specific Tolerance to Multiple Epitopes in T1D

Time: 3:30 pm
day: Day One


  • Discussing how antigen-specific tolerance to multiple proteins stops progression to overt diabetes in the NOD model
  • Tolerance induction by CNP-T1D included upregulation Tregs and TR1 cell populations, which resulted in inhibition of activation of diabetogenic epitopes not encapsulated within CNP
  • The CNP-T1D induced tolerance was durable to the end of the study and also
    prevented infiltration into the islets