Manipulation of TGF-β for Antigen-Specific Immunotherapy of Autoimmune Diseases

Time: 9:30 am
day: Day One


  • Explore how the development of antigen-specific T-cell therapy in animals with established autoimmunity to treat the disease is challenging and hopeful for therapy of patients with autoimmune diseases
  • By manipulation of apoptosis, phagocytosis and TGF-β production in vivo, we have successfully developed an approach to autoantigen-specific Tregs in mice with established autoimmune diseases
  • These in vivo generated antigen-specific Tregs potently suppress inflammation in the target organs, without compromising immunity to cancer and infection