Requirement for Induced Tregs and Tr1 Cells or Regulation of Autoimmune Disease Using Antigen Encapsulating PLG Nanoparticles

Time: 2:30 pm
day: Day One


  • Ag-encapsulating biodegradable PLG nanoparticles (Ag-PLG) induce activation of Tr1 and iTreg cells which are required for tolerance induction and maintenance and dependent on IL-10
  • Ag-PLG can be loaded with recombinant protein to target multiple CD4 and CD8 epitopes simultaneously
  • Ag-PLG therapy has been shown to be effective for inducing tolerance to gluten challenge in celiac disease patients in Phase 1/2a clinical trial