Requirement for Induced Tregs and Tr1 Cells or Regulation of Autoimmune Disease Using Antigen Encapsulating PLG Nanoparticles
Time: 2:30 pm
day: Day One
Details:
- Ag-encapsulating biodegradable PLG nanoparticles (Ag-PLG) induce activation of Tr1 and iTreg cells which are required for tolerance induction and maintenance and dependent on IL-10
- Ag-PLG can be loaded with recombinant protein to target multiple CD4 and CD8 epitopes simultaneously
- Ag-PLG therapy has been shown to be effective for inducing tolerance to gluten challenge in celiac disease patients in Phase 1/2a clinical trial
