8:30 am Morning Networking

9:00 am Opening Remarks from the Chair

Developing Clinically-Relevant Antigen-Specific Tolerogenic Approaches

9:10 am Panel: What Progress Has There Been in Achieving Antigen Specific Therapeutics

• Simi Ahmed Director of Research & Lead of the Immune Therapies Program, JDRF
• Jose Carballido Executive Director (Translational Medicine/ Preclinical Safety), Novartis
• David Wraith Founder & Chief Scientific Officer – Apitope; Director, Institute of Immunology & Immunotherapy, University of Birmingham

10:00 am Success Story: Gliadin-Encapsulating Nanoparticles Induce Gluten-Specific Tolerance in Celiac Disease – Results of A Phase 1/ 2 Placebo-Controlled Clinical Trial

• Ciaran P. Kelly Professor of Medicine/Chief/Director/Medical Director, Harvard Medical School/Herman L. Blumgart Internal Medicine Firm/Gastroenterology Fellowship Training/Celiac Center

10:30 am Challenges in Defining & Measuring Immunological Tolerance in the Long Term

• Andreas Lutterotti Head of Experimental Therapies Research, University Hospital Zurich

11:00 am Digital Speed Networking

Immune Tolerance using Gene Therapy Approaches

11:40 am Challenges and Opportunities for Immune Tolerance Induction in AAV Gene Therapy

• Kei Kishimoto Chief Scientific Officer, Selecta Biosciences

Bringing Antigen Specific Immune Tolerance Therapies to The Clinic

12:10 pm Developing Robust Data to Valid MoA & Demonstrate Clinical Proof of Concept

• David Wraith Founder & Chief Scientific Officer – Apitope; Director, Institute of Immunology & Immunotherapy, University of Birmingham

12:40 pm Lunch & Digital Speed Networking

1:40 pm Developing Suitable Preclinical Models to Enable Successful Clinical Translation

• Dr Bruce Mazer Associate Scientific Director, Strategy , Canadian Covid-19 Immunity Task Force

2:10 pm Induction of cytolytic phenotype in human and mouse CD4+ T-cells by MOG-derived Imotopes™ and validation of the immunosuppressive capacity in mouse models of Multiple Sclerosis

• Antoon Van Oosterhout Chief Scientific Officer VP R&D, Imcyse

2:40 pm Developing Biomarker Assays that Can Inform Both Target Engagement & Pharmacodynamic Effects

• Brendan Classon Vice President Research & Development, Parvus Therapeutics

3:10 pm Networking break

3:40 pm Biomarker-Driven Trial Design and Patient Stratification for Clinical Trials

• Marius Albulescu Global Clinical Program Lead, AstraZeneca

4:10 pm Cell Squeezing RBCs to Create Therapy for Inducing Antigen- Specific Tolerance

• Shinu John Associate Director, Immune Tolerance, SQZ Biotechnologies

The Use of Cell Therapy to Induce Immune Tolerance

4:40 pm Directly Targeting Autoantigen-Specific T-Cells

• Saso Cermerski VP & Head of Discovery & Translational Immunology, Cue Biopharma

5:10 pm Shielded Living Therapeutics (SLTx): A novel allogeneic cell therapy platform for induction of antigen-specific immune tolerance & restoration of immune homeostasis.

• Hozefa Bandukwala Vice President, Platform Innovation and Biology, Sigilon

5:40 pm Chair’s Closing Remarks

5:45 pm End of Day