Carolyn Baloh
Director - Biomarker Research & Discovery, Allergy Portfolio Immune Tolerance Network
Dr Carolyn H Baloh obtained her medical degree at the Pennsylvania State University, her residency in pediatrics at Children’s Hospital of Pittsburgh, and then entered an Allergy/Immunology fellowship at Duke University. She is now an Assistant Professor in Medicine, Harvard Medical School, Mass General Brigham. She is also the Director of Biomarker Research and Discovery for the Allergy Assessment Group of the Immune Tolerance Network (ITN), NIAID. Her research focuses on the induction of tolerance in clinical trials for food and environmental allergies with an emphasis on mechanisms and biomarkers of tolerance. Active projects of particular interest include a trial where she is obtaining lymph node samples in people undergoing allergen immunotherapy and a trial leveraging the microbiome to prevent allergy development.
Seminars
- Analyze biomarker data from landmark peanut-allergy trials (LEAP, IMPACT) to identify reliable predictors of sustained tolerance
- Assess the utility of monitoring circulating Th2a cells as a predictive biomarker for durable clinical tolerance
- Evaluate the relevance of shifts in protective versus pathogenic antibody levels (IgG4/ IgE ratios) as biomarkers of desensitization
- Differentiate the immune mechanisms driving transient desensitization versus durable tolerance in food allergy