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8:50 am Chair’s Opening Remarks
8:59 am
Discussing Development & Clinical Implementation of Tolerizing Therapies to Successfully Navigate the Road to Regulatory Approval that is Unique to Tolerization
9:00 am Facilitating Translation of Tolerization Technologies
Synopsis
- Pre-clinical data is best to specify tolerization mechanism
- Defining clinical tolerization & durability are imperative
- Special considerations of tolerization clinical trial design
Showcasing the Diversity of Technologies & Platforms for Antigen Delivery
9:30 am Large Molecule Drug Development for the Treatment of Myasthenia Gravis
Synopsis
- Showcasing disease-specific proteins as a technology for antigen delivery
- Discussing applications in two different indications
- Sharing thoughts on translation to the clinic
10:00 am Harnessing the Oral Mucosa for Antigen-Specific Immunotherapy of Immune Disorders
Synopsis
- SOMIT is a novel non-invasive oral patch approach leveraging the immune privilege of the oral cavity
- A short-course treatment regimen is achieved by combining prolonged oromucosal antigen presentation with tolerogenic microparticles derived from probiotic bacteria
- SOMIT is a platfom technology applicable to a wide range of immune disorders e.g. autoimmune, ADA, and allergies
10:30 am Virtual Speed Networking & Break
11:00 am Scientific Poster Session
Synopsis
Share and inspire your peers with your research breakthroughs in Antigen-Specific Immune Tolerance
11:30 am A Novel Tolerogenic Dendritic Cell Platform with the Potential to Present the Antigen FVIII to Induce Tolerance Against FVIII in Haemophilia A Patients
Synopsis
- Presentation of a novel and patented platform for generation of tolerogenic DCs
- Hear how the tolerogenic DCs have a potential to induce regulatory T and to reduce antigen-specific T cell responses
- Learn how tolerogenic DCs loaded with FVIII can be used to treat haemophilia A patients who developed inhibitors
12:00 pm The PCFiT Platform: A Promising Approach for B-Cell Directed Allergy Immunotherapy
Synopsis
- B-cell targeting fusion proteins (PCFiT™) elicit a potent allergen specific IgG response
- They are devoid of sensitizing and T-cell activating activity and offer short course, high-dose AIT
- The approach can be broadly applied to all major allergen sources, clinical proof of concept has been demonstrated
12:30 pm A Novel NanoDisc Platform for Systemic Targeting of Lymphoid Tissues and Induction of Antigen-Specific Immune Tolerance
Synopsis
- Exploring how subcutaneous administration of NanoDisc targets multiple lymphoid tissues and immune system organs
- NanoDisc carrying autoantigen induces antigen-specific Tregs and Tr1 cells
- NanoDisc therapy exerts robust efficacy in preclinical models of Multiple Sclerosis and Type 1 Diabetes
1:00 pm Lunch Networking Break
2:00 pm A Nanoparticle Platform for Multiple Immune Tolerance Therapies
Translating Durable & Efficacious Antigen-Specific Immunotherapies into the Clinic
2:30 pm Antigen-Specific Immunotherapy with Thyrotropin Receptor Peptides in Graves’ Hyperthyroidism
Synopsis
- Apitopes® are designed to mimic naturally processed epitopes to restore the immune system’s natural balance (i.e. tolerance to a self-antigen)
- ATX-GD-59 is a peptide mixture of two different, highly soluble apitopes® derived from TSH-receptor. Preclinical studies have demonstrated that ATXGD-59 has a significant impact on the anti-TSHR T cell and B cell response
- A proof of principle study has demonstrated evidence of efficacy in the majority of patients by the reduction of the antibodies and hormones associated with Graves’ disease
3:00 pm Establishing Immune Tolerance in Multiple Sclerosis Using Peptide-Coupled Red Blood Cells
Synopsis
- Development and clinical implementation of a GMP process for peptide coupling using red blood cells from individual patients
- Review of the phase 1b trial including the clinical, safety and immunological data
- Design and implementation of a phase 2 study for clinical proof-of-concept