Building the Biomarker Toolbox for Practical Tolerance Strategies: Evaluating Biomarkers for Determinants of Efficacy, Patient Selection, & Durability
Time: 11:05 am
day: Pre-Conference Workshop Day
Details:
This session is your opportunity to assess your biomarker toolbox from early-stage, preclinical research and practically translate to clinical studies
- Exploring precision medicine to transform the treatment paradigm in autoimmunity
- Delving into the relationship between mechanistic and disease biomarkers
- Designing a biomarker program for clinical trials in antigen-specific tolerization
- Using multiple parameters to understand the mechanisms of tolerization
- Harnessing single-cell transcriptomic data for immune tolerance biomarkers
- Assessing the feasibility of cell assays to develop simpler assays that can be used in clinical phase multi-center studies
- Discussing both patient disease markers and mechanistic markers in tolerance studies, biomarkers of autoimmunity relevant to tolerance
- Assessing functional assays of tolerance
- Demonstrating bystander suppression via biomarkers
- Investing in biomarkers to accelerate biomarkers as a tolerance endpoint – discussing what will regulators accept
