Directing Antigen-Specific Therapies to Precise Tissue Sites & Concentrating the Tolerogenic Signal Where it is Needed Most, & Evaluating the Potential of Tissue-Specific Targeting for Safety & Efficacy
4:00 pm - Wednesday 24th March 2027
- Examining approaches that direct antigen-specific therapies toward a specific organ or tissue, such as the liver, to consider how this may concentrate the tolerogenic effect at the site where it matters most
- Comparing tissue-specific delivery against systemic administration to explore whether targeting a particular site could reduce activity elsewhere in the immune system to improve safety and tolerability while preserving therapeutic activity where it is needed
- Discussing how tissue-specific targeting might influence dosing frequency and route of administration to consider what this could mean for patient burden and trial design
