David Fox
Professor Rheumatology, Internal Medicine University of Michigan, Immune Tolerance Network, Abcon
David A Fox, MD. Dr. Fox is a graduate of the Massachusetts Institute of Technology and Harvard Medical School. Following internal medicine residency and rheumatology fellowship at the Brigham and Women’s Hospital, he joined the faculty of the University of Michigan School of Medicine in 1985. Dr. Fox is Professor of Internal Medicine and, from 1990 to 2018, was Chief of the Division of Rheumatology. In 2013, Dr. Fox became the Frederick G. L. Huetwell and William D. Robinson, M.D. Professor of Rheumatology. He is currently a Deputy Director of the Immune Tolerance Network.
Dr. Fox’s research focuses on defining and characterizing pathways of human T cell activation, determining the role of these pathways in the pathogenesis of autoimmune disease, investigating T cell interactions with synovial fibroblasts, and exploring novel approaches to the treatment of rheumatoid arthritis and scleroderma. His laboratory recently discovered that a shed form of the cell surface CD13 ectoenzyme mediates profound inflammatory effects through binding to the bradykinin 1 receptor. His laboratory is also studying CD6 as a new target for both autoimmunity and cancer immunotherapy. Dr. Fox is an author of more than 300 scientific papers and book chapters. From 2007-2008, Dr. Fox served as the seventy-first President of the American College of Rheumatology and the sixth ACR President from the University of Michigan.
Seminars
- Explore how selective immune modulation can control disease-driving responses while preserving protective immunity to improve therapeutic safety and long-term patient outcomes
- Assess strategies to induce immune tolerance while maintaining anti-tumor immunity, expanding the therapeutic potential of ASIT approaches across diseases
- Analyzing the distinctions in the molecular interactions between anti-CD6 and CD4+ versus CD8+ T-cells
