Examining Mechanistic Biomarkers in Food Allergies to Distinguish Transient Desensitization from Sustained Tolerance & Reveal What Defines a Truly Durable Immune Response
11:30 am - Wednesday 24th March 2027
- Analyze biomarker data from landmark peanut-allergy trials (LEAP, IMPACT) to identify reliable predictors of sustained tolerance
- Assess the utility of monitoring circulating Th2a cells as a predictive biomarker for durable clinical tolerance
- Evaluate the relevance of shifts in protective versus pathogenic antibody levels (IgG4/ IgE ratios) as biomarkers of desensitization
- Differentiate the immune mechanisms driving transient desensitization versus durable tolerance in food allergy
