Aaron Winkler
Company: Pfizer
Job title: Immune Tolerance Lead & Research Fellow, Inflammation & Immunology
Seminars:
Panel Discussion: Tissue Vs Antigen Specificity: Considering Larger Patient Populations & More Complex Diseases 3:00 pm
• Examining the instances in which a tissue-specific response might be superior to an antigen specific-immune response • Harnessing the epitope-spreading phenomena to develop ASIT therapies for diseases with unknown antigens • Evaluating the risks of tissue-specific approaches being immunosuppressive rather than resetting the immune systemRead more
day: Custom Day Two
Chair’s Opening Remarks 8:50 am
day: Seminar Day
Panel Discussion: Current Approaches for Profiling the Autoimmune Response to Inform the Development of ASIT Therapies 9:00 am
• Utilizing autoantigenic peptides to promote tolerogenic APCs and Treg cells to induce antigen specific immune tolerance • Depleting autoreactive B cells, providing a targeted approach to minimizing autoimmune responses without suppressing the immune system • Discussing current approaches to T-cell sequencing to enable a detailed understanding of the immune repertoire and aid the identification…Read more
day: Seminar Day
Panel Discussion: Harnessing Technologies for Antigen Discovery & Selection 3:30 pm
• Reviewing the landscape of technologies for antigen discovery and selection in development • Approaches for antigen selection in diseases with well-defined antigens such as Type 1 Diabetes and Multiple Sclerosis • Evaluating the potential for tackling complex, heterogenous diseases with antigen-specific immune tolerance approachesRead more
day: Seminar Day pt 3