David Easterhoff

Company: Moderna

Job title: Director

Seminars:

LNP-MRNA Strategies to Restore Immune Homeostasis in Autoimmune Indications 9:30 am

• Antigen discovery and selection for autoimmune diseases • The potential for mRNA therapeutics to restore immune homeostasis • Preclinical animal studies demonstrating safety and tolerability for mRNA medicinesRead more

day: Custom Day Two

Panel: Debating the Need for Autoantigens Vs Tissue Specific Antigens 12:00 pm

• Understanding the interplay between disease-specific and tissue-specific antigens • Addressing the challenges posed by antigen heterogeneity using T1D as a case study • Is having a strong pancreatic antigen to induce Tregs in the pancreas enough to trigger antigen-specific immunity in T1D patients?Read more

day: Seminar Day pt 2

Panel Discussion: Current Approaches for Profiling the Autoimmune Response to Inform the Development of ASIT Therapies 9:00 am

• Utilizing autoantigenic peptides to promote tolerogenic APCs and Treg cells to induce antigen specific immune tolerance • Depleting autoreactive B cells, providing a targeted approach to minimizing autoimmune responses without suppressing the immune system • Discussing current approaches to T-cell sequencing to enable a detailed understanding of the immune repertoire and aid the identification…Read more

day: Seminar Day