Kristie Grebe
Company: Anokion
Job title: Chief Scientific Officer
Seminars:
Panel Discussion: Practical Approaches for Creating a Compelling Preclinical Data Package for IND Submission to Move ASIT Therapies from the Lab to the Clinic 1:00 pm
• Highlighting the importance of robust clinical data to secure funding, partnerships, and regulatory buy-in in a new area with limited proof-of-concept studies • Turbocharging the development of humanized mouse models and organoids to accurately replicate human autoimmune diseases for increased preclinical data • Evaluating strategies for first in-human trials: when and where should the…Read more
day: Custom Day Two
Panel Discussion: Future Directions in Tolerizing Therapies 3:30 pm
• Creating a convincing preclinical data package to ignite regulatory excitement and push more ASIT therapies toward the clinic • Strategies for determining clinical endpoints by phase of development – are surrogate endpoints the way forward? • Assessing optimal modalities and disease areas for future development – are cell therapies the future of ASIT? Will…Read more
day: Custom Day Two
Clinical evidence of Immune Tolerance Induction: examples from Celiac Disease and Multiple Sclerosis 9:00 am
• Measuring immune tolerance through biomarkers in Celiac Disease • Detection of antigen-specific tolerance to myelin-based autoantigens in MS; evaluation of bystander suppression and durability of responses • Maximising patient safety in early clinical trials for inducing immune tolerance in the CNSRead more
day: Conference Day One
Panel Discussion: Redesigning Clinical Trials for Immune Tolerance Therapies: Enhancing Safety, Efficacy, and Regulatory Compliance 12:00 pm
• Uncovering the limitations of autoimmune disease models in the context of the maturity of the autoimmune response in mice compared with humans • Addressing the regulatory hurdles involved in using a biologic and a chemical component in ASIT therapies • Looking at the potential for a changing paradigm in clinical development for precision medicine…Read more
day: Conference Day One